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The recent study by Greenberg and Cello¹ reached negative conclusions regarding the opportunity to eradicate Helicobacter pylori in patients with nonulcer dyspepsia. The authors found that, at 1 year, the change in dyspeptic symptoms was the same in the group receiving an eradicating treatment as in the placebo group. Furthermore, patients with persistent H pylori infection showed a greater, but not significant, improvement in symptoms than those with successful eradication during the follow-up.

Literature data on the role of H pylori infection in nonulcer dyspepsia are somewhat controversial. Blum et al² substantially confirmed the results of Greenberg and Cello. On the contrary, Jaakkimainen et al,³ reporting the results of a meta-analysis of 23 observational studies, recently found that for patients in whom H pylori was eradicated, dyspeptic symptoms were 90% more likely to improve compared with patients in whom the infection was not eliminated.

However, we have identified problems with . . . [Full Text of this Article]

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Lack of Effect of Treatment for Helicobacter pylori on Symptoms of Nonulcer Dyspepsia
Paul D. Greenberg and John P. Cello
Arch Intern Med. 1999;159(19):2283-2288.
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