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Hypertensive Crisis Following Meperidine Administration and Chemoembolization of a Carcinoid Tumor
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A 70-year-old woman with a metastatic carcinoid tumor in the liver was admitted to the hospital for management of systolic hypertension following chemoembolization. The patient underwent chemoembolization through catheterization of the left hepatic artery with 60 mg of doxorubicin hydrochloride in 10 mL of diatrizoate meglumine. One hour and 30 minutes prior to initiation of chemoembolization, the patient was given octreotide acetate, dexamethasone sodium phosphate, and 10 mg per hour of meperidine hydrochloride by continuous intravenous infusion.1 The patient had previously experienced severe nausea from intravenous morphine; therefore meperidine was selected for narcotic anaglesia.
Thirty minutes into the procedure, the patient became hypertensive with a systolic blood pressure of 235 mm Hg. The chemoembolization procedure was completed, but the patient remained hypertensive. The medical service was called to assist with the management. The patient received 5 mg of labetalol hydrochloride intravenously, nitroglycerin paste, and 0.625 mg of enalapril maleate intravenously, . . . [Full Text of this Article]
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