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As an allergist and immunologist interested in the mechanism of development of allergy and asthma, I read with interest the recent report by Camargo et al¹ regarding the association of obesity with asthma in women. Wilson and Irwin,² in the accompanying editorial, identify the limitations of the study, particularly the inherent difficulty in associating 2 common disorders as somehow responsible for each other. Wilson and Irwin offer some possible confounding factors, such as the association of obesity with gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA), and their potential role in the development of asthma symptoms. Despite the known role of inflammation in asthma, Wilson and Irwin² did not mention possible immunologic mechanisms for this association.

I have proposed a theory regarding the role of cyclooxygenase-2 (COX-2) in the development of allergy and asthma,^3-4 which may also explain the association of obesity with asthma based on what is known . . . [Full Text of this Article]

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