This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on ISI (19)  • Contact me when this article is cited  Related Content  • Similar articles in this journal

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Ienjoyed reading the excellent review article on St John's wort by Gaster and Holroyd,¹ with a balanced view on the pros and cons of its use for treatment of mental depression. As the authors indicated, the use of St John's wort has increased markedly worldwide in recent years, with annual sales of $200 million in the United States in 1997² and 111 million daily doses sold in Germany in the same year.³ This wide use is in contrast to the poor understanding of the pharmacokinetics, including drug interactions, of constituents of extract of St John's wort (Hypericum perforatum).

One particular drug-herb interaction that is of great clinical significance is the interaction of St John's wort with digoxin. Johne et al⁴ recently reported that 10 days' use of St John's wort could result in a decrease of digoxin serum concentration (or more precisely, the digoxin area under the plasma . . . [Full Text of this Article]

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

BLOCKADE OF {gamma}-AMINOBUTYRIC ACID RECEPTORS DOES NOT MODIFY THE INHIBITION OF ETHANOL INTAKE INDUCED BY HYPERICUM PERFORATUM IN RATS
Perfumi et al.
Alcohol Alcohol 2002;37:540-546.
ABSTRACT | FULL TEXT  

St John's Wort and Literature Quotations
Mennini et al.
Arch Intern Med 2001;161:1016-1017.
FULL TEXT