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Influenza vaccination (IV) has rarely been associated with serious adverse effects, such as Guillain-Barré syndrome, systemic lupus erythematosus, rheumatoid arthritis, polymyalgia rheumatica, and vasculitis.^1-7 Giant cell arteritis (GCA) is a large-vessel vasculitis, with a granulomatous arteritis of the aorta and its major branches and a predilection for the extracranial branches of the carotid artery.⁸ To our knowledge, GCA occurring after IV has not been previously reported. We report a case of GCA that developed after IV in a patient who was positive for HLA-DRB1*04, which has been associated with GCA susceptibility.⁹

Report of a Case

A previously healthy 76-year-old woman presented with a 3-week history of severe headache, pain on chewing, malaise, fatigue, anorexia, and weight loss. Her medical history was significant for IV 1 week before the onset of her complaints. The results of her physical examination were normal. Laboratory investigations revealed an erythrocyte sedimentation rate of 105 mm/h, leukocytosis (white blood cell . . . [Full Text of this Article]

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