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Chronic diarrhea is a frequent complaint in patients with acquired immunodeficiency syndrome (AIDS). In most cases, the cause of diarrhea remains unexplained after extensive evaluation. The presence of intestinal injury and dysfunction in the absence of pathogens was an early observation in patients with AIDS,¹ and the name human immunodeficiency virus (HIV) enteropathy was introduced in an attempt to group such patients into a single entity. Structural and functional findings in patients with HIV enteropathy are similar to those found in patients with celiac disease. In such patients, diarrhea usually resolves after treatment with a gluten-free diet.^2-3 The purpose of this article was to investigate the effect of a gluten-free diet in patients with HIV enteropathy.

Patients and Methods

We enrolled patients with HIV infection and diarrhea that had lasted 30 days or longer. Opportunistic enteric infections and/or carcinoma were ruled out. Workup included upper and lower endoscopy and biopsy. The . . . [Full Text of this Article]

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