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Cholestatic Liver Reaction and Heparin Therapy
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Many drugs may lead to liver injury, including acute or cholestatic hepatitis. However, drug-induced hepatitis is often a presumptive diagnosis, as it is difficult to establish evidence of clear causal relationships between the use of certain drugs and liver damage. We report a case of cholestatic liver reaction associated with the use of heparin.
Report of a Case
A 54-year-old man started complaining of dyspnea and sharp dorsal pain on his right side. Six days earlier he had been operated on for the repair of a right inguinal hernia. Results of a full panel of laboratory tests performed before the operation were quite normal. The following day, a chest radiograph revealed a small consolidation at the base of the right lung, and a general practitioner prescribed 5000 IU of heparin calcium every 12 hours. Three days later, with the thoracic pain persisting, the patient was admitted to our department. The patient's pulse rate, blood . . . [Full Text of this Article] Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Drug-Induced Hepatotoxicity
Juurlink et al.
NEJM 2003;349:1974-1976.
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