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Successful Treatment With Combination Therapy of Cyclophosphamide and Cyclosporin for Late Recurrence of Wegener Granulomatosis
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Although the mortality of Wegener granulomatosis (WG) has been decreased significantly by treatment with cyclophosphamide, recurrence is also widely reported. Cytoplasmic pattern antineutrophil cytoplasmic antibody (C-ANCA) is considered an important marker for demonstrating the disease's activity. Therefore, if WG does not flare-up on long-term follow-up of more than 15 years and if C-ANCA and other inflammatory signs do not relate to clinical manifestations, it may be difficult to understand the condition of the patient and to treat the disease when it recurs. We present a case of WG manifesting 2 necrotic lesions and 1 granulomatous lesion (ie, oral mucosa, cornea, and trachea after an 18-year period of clinical stability).
Report of a Case
In April 1999, a 36-year-old woman was admitted to our hospital because of a 2-week history of stridor on vigorous exertion. She had been diagnosed as having WG proven by skin biopsy at the age of 16 years, and she was . . . [Full Text of this Article]
Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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What Is Proper Treatment for Wegener Granulomatosis?
Inoue et al.
Arch Intern Med 2001;161:1777-1778.
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