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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In the report by Guardiola and colleagues,¹ a switch in protease inhibitor (PI) therapy for reasons other than therapeutic failure occurred in 74% of patients who were treated with PI-based regimens. The therapeutic strategy in these patients needs careful assessment before PI changes, since the patients may be put at greater risk for therapeutic failure after therapy change.

Figure 1 shows the virologic response in 14 patients who had a switch in PI after having achieved viral RNA suppression (viral RNA load <400 copies per milliliter) compared with 28 patients who continued to receive a successful regimen. Patients from 2 clinics were included in this retrospective chart review if they were treated with an indinavir sulfate regimen for at least 6 months and had 2 viral RNA measures below detection while receiving indinavir-combination therapy.² From this group, patients were further identified for the switch group if their PI therapy had . . . [Full Text of this Article]

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