This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (27)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Celecoxib (Celebrex; Searle & Co Pharmaceuticals, Skokie, Ill, and Pfizer Inc, New York, NY) is a new and popular nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase 2.¹ It is approved for the treatment of both rheumatoid arthritis and osteoarthritis. Recognized adverse reactions include gastrointestinal hemorrhage, hepatitis, abdominal pain, and diarrhea. It should not be administered to patients with allergies to sulfa drugs. Acute pancreatitis has not been reported with the use of celecoxib.

Report of a Case

An 84-year-old woman presented with severe abdominal pain 2 days after she began taking celecoxib for knee pain. Her medical history was significant for hypertension, mild hypertriglyceridemia, and a cholecystectomy in the distant past. Her medications included estrogen (Premarin) and a thiazide diuretic. She reported an allergy to sulfa medication and denied alcohol intake.

Results
On physical examination, the patient was afebrile and nonicteric. Abdominal examination revealed severe epigastric tenderness without peritoneal signs. Laboratory findings on admission . . . [Full Text of this Article]

Comment


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sulfonamide Cross-Reactivity: Fact or Fiction?
Johnson et al.
The Annals of Pharmacotherapy 2005;39:290-301.
ABSTRACT | FULL TEXT  

Drug-Induced Hepatotoxicity
Lee
NEJM 2003;349:474-485.
FULL TEXT  

Comment: acute cholestatic hepatitis associated with celecoxib
Waldum
The Annals of Pharmacotherapy 2003;37:748-749.
FULL TEXT  

Celecoxib-Induced Cholestatic Hepatotoxicity in a Patient with Cirrhosis
Alegria et al.
ANN INTERN MED 2002;137:75-75.
FULL TEXT  

Acute hepatocellular and cholestatic injury in a patient taking celecoxib
Nachimuthu et al.
Postgrad. Med. J. 2001;77:548-550.
ABSTRACT | FULL TEXT