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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We were disappointed by the article by Morello et al¹ that was recently published in the ARCHIVES. It is our opinion that their discussion was misleading and their conclusions were iniquitous.

A total of 19 evaluable patients is not a sufficient number to arrive at any statistically significant conclusions in a double-blind study, especially with ordinal data. The authors admit that "260 patients per paired crossover study would be necessary to provide 80% power to detect a mean difference between treatments of approximately one third of the difference between mild and moderate pain at a .05 significance level." Nevertheless, the authors conclude that "mean pain diary and global pain relief score data indicate no statistical difference" between gabapentin and amitriptyline therapy in relieving pain.

Several citations concur that in order to achieve maximum benefit with amitriptyline therapy, minimum dosages of 75 to 150 mg/d should be used.^2-3 Acceptable dosages of . . . [Full Text of this Article]