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Arch Intern Med. 2000;160:1229-1230.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

VITAMIN B₁₂ deficiency is estimated to affect 10% to 15% of the people older than 60 years.¹ The most common causes of cobalamin (vitamin B₁₂) deficiency are pernicious anemia and food-cobalamin malabsorption. These are distinct entities that can be readily distinguished by a Schilling test. Pernicious anemia and food-cobalamin malabsorption also share several similarities, namely, an increasing prevalence with age, an association with types of chronic gastritis, and most recently, a link to Helicobacter pylori infection.

Cobalamin is obtained exclusively from the diet, with animal proteins being the primary source.¹ Cobalamin absorption is a complicated process involving several steps of digestion prior to gastrointestinal absorption.² Thus, there are multiple causes by which cobalamin absorption can be decreased, resulting in cobalamin deficiency. Peptic digestion in an acidic environment is required to release cobalamin from food proteins and allow for binding to R proteins. Excess cobalamin binds to another cobalamin-binding protein, . . . [Full Text of this Article]

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Arch Intern Med. 2000;160(9):1349-1353.
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