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Systematic Reviews Neglect Safety Issues
Arch Intern Med. 2001;161:125-126.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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The concept of evidence-based medicine is as simple as it is compelling
and has indisputably had a major influence on modern therapeutics. Evidence-based
medicine aims to objectively evaluate all medical interventions with a view
of translating this knowledge into routine medical practice and thus enhancing
patient care. One of its most powerful tools to achieve this aim is the systematic
review (SR).1 Systematic reviews, including
meta-analyses, aim at impartially assessing the evidence for a given treatment
and usually focus on efficacy or effectiveness. Yet safety data are equally
important for evidence-based decisions about the value (or otherwise) of therapeutic
interventions.
To determine to what extent safety issues have been the subject of SRs,
the literature was searched using MEDLINE (1966 to November 1999). The search
terms were "systematic review," "meta-analysis," "efficacy," "effectiveness,"
"safety," "adverse effects," "adverse reactions," and derivatives of these
terms. Identified articles were categorized according to the time . . . [Full Text of this Article]
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