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Clinical Signs and Symptoms Predicting Influenza Infection
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Because influenza vaccines are not fully protective against influenza
A and B, immediate treatment with neuraminidase inhibitors could further reduce
the annual morbidity and mortality associated with influenza (notably in the
presence of high-risk conditions). As described by Monto et al,1
more studies are needed on early recognition of influenza infection on the
basis of demographics, comorbidity, and signs and symptoms. We believe, however,
that owing to the selection of the study subjects and incomplete statistical
analysis performed by Monto et al, their study results are of little value
to practicing physicians.
Monto et al1 included a highly select
population of relatively young, healthy people with fever or a symptom of
feverishness and 2 or more influenza-like symptoms. Also, most of the participants
reported onset of symptoms within the preceding 36 hours. It is not surprising,
therefore, to find laboratory-confirmed influenza infection in 66% of these
patients. In primary care . . . [Full Text of this Article]
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