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Arch Intern Med. 2001;161:1379-1380.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

THE ARTICLE by Cui et al¹ reports that non–high-density lipoprotein cholesterol (non–HDL-C) is a somewhat better predictor of cardiovascular disease mortality than is low-density lipoprotein cholesterol (LDL-C) in the Lipid Research Clinics Follow-up Study. The authors note that the National Cholesterol Education Program (NCEP) has identified LDL-C as the primary target of therapy for lowering cholesterol levels.^2-3 However, if non–HDL-C level is a better predictor of cardiovascular disease than is LDL-C level, perhaps non–HDL-C should replace LDL-C in risk prediction and should be the primary target of therapy for lowering cholesterol levels.

Non–HDL-C includes the cholesterol contained in the following 3 lipoprotein fractions: LDL, intermediate-density lipoprotein (IDL), and very-low-density lipoprotein (VLDL). In clinical lipoprotein analysis, LDL and IDL are usually combined into a single fraction termed LDL.⁴ Non–HDL-C is theoretically attractive as a predictor and as a target of therapy for several reasons. First, it includes not only LDL-C . . . [Full Text of this Article]

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