This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (20)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Sports Medicine  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Intern Med. 2001;161:1455-1456.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Over the past decade, creatine has become a popular dietary supplement among professional and recreational athletes because of its reported beneficial effects on exercise performance.¹ With worldwide annual consumption estimated to be approximately 2.5 x10⁶ kg, it can currently be classed as one of the world's best-selling dietary supplements.¹ An increase in creatine intake will suppress endogenous production of creatine.^2-3 Under normal conditions, creatine synthesis in the liver accounts for nearly 75% of daily homocysteine formation^4-5 (Figure 1). An elevated plasma homocysteine concentration is considered an important independent risk factor in the development of cardiovascular disease⁶; therefore, it is important to establish whether dietary creatine supplementation influences plasma homocysteine concentration. One might predict that an increase in exogenous creatine supply would decrease plasma homocysteine concentration as a consequence of diminished endogenous creatine production (Figure 1), but there are currently no published data available to . . . [Full Text of this Article]

Subjects, Materials, and Methods


Results

Comment


CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The effect of l-arginine and creatine on vascular function and homocysteine metabolism
Jahangir et al.
Vasc Med 2009;14:239-248.
ABSTRACT  

Methyl balance and transmethylation fluxes in humans
Mudd et al.
Am. J. Clin. Nutr. 2007;85:19-25.
ABSTRACT | FULL TEXT  

Is it time to reevaluate methyl balance in humans?
Stead et al.
Am. J. Clin. Nutr. 2006;83:5-10.
ABSTRACT | FULL TEXT  

Facts and Recommendations about Total Homocysteine Determinations: An Expert Opinion
Refsum et al.
Clin. Chem. 2004;50:3-32.
ABSTRACT | FULL TEXT