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Arch Intern Med. 2001;161:1456-1457.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We report the case of a patient who developed eosinophilic fasciitis, possibly induced by the 3-hydroxy-3-methylglutaryl coenzyme A reductase, simvastatin.

Report of a Case

A 66-year-old woman presented with myalgias of the legs and arms associated with muscle weakness and erythrosis of the face 18 months after beginning oral treatment with 20 mg of simvastatin daily for primary hypercholesterolemia. She had no history of atopy, asthma, or chronic disease. She had not traveled out of France for the previous 12 months. Three months after the first symptoms began, she suffered from proximal muscle weakness, peripheral edema, and fasciitis on the flank and forearms. An electromyogram showed signs of myositis. Creatine kinase and lactic acid dehydrogenase levels remained within normal limits, but aldolase levels were elevated (9 U/L; normal, <7.6 U/L), as were eosinophil counts (1.4 x 10⁹/L). Results of a histological examination of a deep cutaneous biopsy specimen were suggestive of eosinophilic fasciitis: . . . [Full Text of this Article]

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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