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Causes of Death in Patients With Systemic Lupus Erythematosus in São Paulo, Brazil: A Study of 113 Autopsies
Arch Intern Med. 2001;161:1557.
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The mortality of patients with systemic lupus erythematosus (SLE) decreased
between 1954 and 1974 from 50% survival over 4 years to more than 90% survival
over 10 years.1 However, these rates have
since remained unchanged.
Report of a Study
We performed a retrospective study of inpatients with the diagnosis
of SLE who died at a 2000-bed teaching hospital in São Paulo, Brazil,
from January 1981 to December 1994: 1427 inpatients with SLE were registered
in the hospital; 13.9% died, and 113 autopsies were performed (100 women and
13 men; mean ± SD age, 31.3 ± 11.7 years). Of these, 58% had
infection as the major cause of death. Fungus and tuberculosis were together
responsible for 13% of all deaths.
Background
An increasing number of fatal infections occur among patients with SLE.
In fact, infections are the leading cause of death according to some studies.2-3 In addition, most of the opportunistic
infections that cause death are . . . [Full Text of this Article]
Methods
Results
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