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Arch Intern Med. 2001;161:1778.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A combination drug consisting of chlordiazepoxide hydrochloride and clidinium bromide (Librax) is frequently prescribed for irritable bowel disease, as it combines the antianxiety action of chlordiazepoxide and the anticholinergic and spasmolytic effects of clidinium. We report a case of acute thrombocytopenic purpura that developed during chlordiazepoxide-clidinium therapy.

Report of a Case

A 68-year-old man was admitted for rhinorrhagia and generalized petechiae. He had been receiving lorazepam, perphenazine, and amitriptyline hydrochloride for many years. Two months before his admission, chlordiazepoxide hydrocloride–clidinium bromide was prescribed at a dosage of 5 mg of chlordiazepoxide and 2.5 mg of clindinium 3 times per day for irritable bowel disease. On admission, his spleen was not palpable. A peripheral blood sample revealed a low platelet count (15 x 10³/µL). The total white blood cell count, leukocyte differential cell count, and hemoglobin level were normal. The fibrinogen concentration, prothrombin time, and partial thromboplastin time were also normal. A bone marrow . . . [Full Text of this Article]

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