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Possible Relationship Between Statin Use and Decreased Incidence of Dementia: Are We Ready for a New Indication for These Drugs?
Arch Intern Med. 2001;161:1909-1910.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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In an article titled "Statins and the Risk of Dementia" published in
the November 11, 2000, issue of Lancet, Jick and
colleagues1 from Boston, Mass, reported
an epidemiologic, observational, nested case-control study of subjects enrolled
in the United Kingdom-based General Practice Research Database. Records of
patients aged 50 to 89 years were classified into 1 of 3 groups: group 1 comprised
individuals who received at least 1 prescription of lipid-lowering agents
(LLAs) within the previous 6 months; group 2, all individuals with a clinical
diagnosis of untreated hyperlipidemia; and group 3, a randomly selected group
of other individuals.
From this base population, all cases with a computer-recorded diagnosis
of dementia or Alzheimer disease (AD) entered between 1992 and 1998 were identified,
and each case was matched with up to 4 controls. Excluded from the study were
patients with diagnoses of alcoholism or drug abuse, cancer, motor neuron
disease, parkinsonism, . . . [Full Text of this Article]
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