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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The article by Klungel et al¹ has strengthened the growing evidence for the role of thiazide diuretics, which are relatively cheaper and probably safer, as first-line antihypertensive agents. Thiazide diuretics have been the standard treatment for hypertension in Great Britain for a long time.² It is noteworthy that they also are useful in the treatment of osteoporosis,³ to which many hypertensive patients are predisposed because of common risk factors such as age, sedentary lifestyle, and smoking.

Although Klungel and colleagues' study did consider many confounding factors, we wish to discuss some relevant points. It is not clear as to what the composition of the population in the 2 groups was in terms of racial background, as it is known that ischemic stroke cases involving African American patients have a worse prognosis than those involving whites at any level of BP.⁴

Also, it would have been helpful to know about the . . . [Full Text of this Article]

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Antihypertensive Drug Therapies and the Risk of Ischemic Stroke
Olaf H. Klungel, Susan R. Heckbert, W. T. Longstreth, Jr, Curt D. Furberg, Robert C. Kaplan, Nicholas L. Smith, Rozenn N. Lemaitre, Hubert G. M. Leufkens, Anthonius de Boer, and Bruce M. Psaty
Arch Intern Med. 2001;161(1):37-43.
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