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Myoclonus and Generalized Seizures Associated With Gatifloxacin Treatment
Arch Intern Med. 2001;161:2261-2262.
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Fluoroquinolones are widely used in the treatment of community-acquired
urinary and respiratory tract infections. While the safety profile of these
agents is established, neurotoxicity has been associated with ciprofloxacin,
ofloxacin, pefloxacin, norfloxacin, and alatrofloxacin.1-2
Reported below is the case of an elderly woman who developed myoclonus and
generalized seizures while receiving gatifloxacin therapy for a urinary tract
infection.
Report of a Case
An 87-year-old woman with Alzheimer dementia was admitted to the hospital
with a urinary tract infection and poor oral intake. The patient was a poor
historian but denied complaints. There was no history of seizures or other
medical disorders. Admission vital signs were normal. Physical examination
results were remarkable only for impaired cognition. Findings were normal
for platelet and leukocyte counts and levels of serum sodium, potassium, calcium,
hemoglobin, creatinine, urea nitrogen, anion gap, and glucose. Results from
a urinalysis revealed pyuria and bacteriuria. The patient was administered
400 mg of intravenous . . . [Full Text of this Article]
Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Possible Gatifloxacin-Induced Seizure
Quigley and Lederman
The Annals of Pharmacotherapy 2004;38:235-237.
ABSTRACT
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