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High Level of High-Density Lipoprotein Cholesterol (HDL-C) Does Not Attenuate Increased Risk of Elevated Triglycerides
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In a recent and otherwise very thorough review of cardiovascular disease
and dyslipidemia in women, the author makes the unreferenced statement that
"[a]verage or high HDL cholesterol levels appear to attenuate triglyceride-associated
CHD [coronary heart disease] risk."1 This
follows the referenced and well-supported statement that low HDL-C levels
in the presence of hypertriglyceridemia identifies particularly high-risk
patients. While it is tempting to assume that higher HDL-C concentrations
are uniformly protective, this has recently and specifically been shown not
to be the case in the presence of elevated triglyceride concentrations. In
a review of the 8-year Copenhagen Male Study, Jeppesen et al2
found that in patients with the highest tertile of triglyceride concentration
(mean, 216 mg/dL [2.4 mmol/L]), both a low HDL-C level (mean, 38 mg/dL [0.98
mmol/L]) and a high HDL-C level (mean, 67 mg/dL [1.7 mmol/L]) were associated
with a higher incidence of ischemic heart disease compared with average . . . [Full Text of this Article]
RELATED ARTICLE
Cardiovascular Disease and Dyslipidemia in Women
Francine K. Welty
Arch Intern Med. 2001;161(4):514-522.
ABSTRACT
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