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Accuracy and Ambiguity in Counseling Patients About Genetic Risk
Farrell J. Lloyd, MD, MPH;
Valerie F. Reyna, PhD;
Patrick Whalen, BA
Arch Intern Med. 2001;161:2411-2413.
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INTRODUCTION
A patient from Phoenix, Ariz, recently diagnosed
as having diabetes mellitus has a deep tan. He read about hemochromatosis
on a Web site and is concerned that he might have the condition. His mother
died of congestive heart failure and his paternal uncle had diabetes mellitus
and severe arthritis. He wants to obtain testing for an HFE gene mutation. He asks, "If I have the gene, could that be the reason for
my diabetes mellitus? What should I do if I am tested and I have the gene?
If I do not have the gene, could I still have the disease? Should my children
be tested?"
Recent research has greatly increased knowledge of gene mutations that
are responsible for a wide array of diseases. As basic science increases the
understanding of these mutations, clinicians are asking if there . . . [Full Text of this Article]
PHYSICIANS AND GENETIC COUNSELING
GENETICS AND HEMOCHROMATOSIS
VISUAL REPRESENTATIONS OF POSTTEST PREDICTIVE VALUES
SUMMARY
From the Department of Internal Medicine (Dr Lloyd), Mayo Clinic Scottsdale,
Scottsdale, and the Departments of Surgery (Dr Reyna and Mr Whalen) and Internal
Medicine (Dr Reyna), University of Arizona, Tucson.
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