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Complete Resolution of Reflex Sympathetic Dystrophy With Thalidomide Treatment
Arch Intern Med. 2001;161:2502-2503.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Reflex sympathetic dystrophy (RSD) is a disabling syndrome of regional
pain, sensory changes, and edema following a noxious event.1
The pathogenesis is believed to be related to an increased rate of efferent
sympathetic nerve impulses toward the involved extremity induced by increased
afferent activity. Thus, therapy has been aimed at interrupting sympathetic
nerve activity medically, surgically, or chemically.1-2
Therapy for RSD is disappointing, and patients experience a significantly
poor quality of life. We report a serendipitous dramatic resolution of RSD
in a patient treated with thalidomide for recently diagnosed myeloma unrelated
to her RSD.
Report of a Case
A 43-year-old woman with a history of severe RSD was seen for treatment
of newly diagnosed multiple myeloma. Three years ago she developed RSD involving
the left-upper and left-lower extremities following a traumatic injury to
her left hand. The symptoms included atrophy of muscles of the left hand with
contractures of the digits, severe attacks of . . . [Full Text of this Article] Comment
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