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Monoamine Oxidase Deficiency: A Cause of Flushing and Attention-Deficit/ Hyperactivity Disorder?
Arch Intern Med. 2001;161:2503-2504.
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It is not uncommon for a patient to present to a physician with the
complaint of flushing. Differential diagnoses include menopause, thyrotoxicosis,
medications, alcohol, carcinoid syndrome, pheochromocytoma, medullary carcinoma
of the thyroid, and systemic mastocytosis.1
Sometimes no cause is identified. In this case report, we describe a family
with a novel cause of flushing and diarrhea, most likely the consequence of
a hereditary enzymatic defect. Such a disorder may account for some idiopathic
cases of flushing and, as illustrated by our subjects, might even be a cause
of attention-deficit/hyperactivity disorder (ADHD).
Report of Cases
A 42-year-old woman presented with a history of flushes, headaches,
and diarrhea. From the age of 30 years, she had experienced chronic diarrhea,
up to 5 to 6 times daily, with crampy abdominal pain. Gastroscopy and colonoscopy
had demonstrated no abnormalities, and she was considered to have irritable
bowel syndrome. At the age of 33 years, she developed migraines. . . . [Full Text of this Article]
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RELATED LETTER
Monoamine Oxidase Deficiency: A Cause of Symptomatic Hyperserotoninemia in the Absence of Carcinoid
Richard R. P. Warner, N. Wah Cheung, and John Earl
Arch Intern Med. 2002;162(14):1647-1648.
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Monoamine Oxidase Deficiency: A Cause of Symptomatic Hyperserotoninemia in the Absence of Carcinoid
Warner et al.
Arch Intern Med 2002;162:1647-1648.
FULL TEXT
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