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Duration of the Hypocholesterolemic Effect of Garlic Supplements
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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The systematic review by Ackermann et al1
of 45 controlled clinical trials on cardiovascular end points with garlic
supplements represents an exhaustive and careful undertaking that has revealed
problems in the design and blinding of many of the trials as well as the inconsistent
or unknown quality of many of the products used in the trials. I am in agreement
with all of the conclusions and criticisms expressed in the report, with one
exception.
The authors have concluded from Forest plot C (see the Figure in their
article) that the effects of garlic supplements on serum cholesterol levels
may only be of short duration. The comparison of the pooled results at 8 to
12 weeks with those at 20 to 24 weeks in plot C indicates that the significant
cholesterol levellowering effect found at 8 to 12 weeks is substantially
reduced and insignificant at 20 to 24 weeks. However, there . . . [Full Text of this Article]
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