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Cancer Antigen 125: Tumor or Serosal Marker in Case of Ascites?
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We read with great interest the case report published in a recent issue
of the ARCHIVES.1 Au et al described a 45-year-old
woman with severe weight loss and ascites of about 2 months' duration. The
abnormal laboratory findings were hypoalbuminemia (16 g/L) and elevated levels
of serum cancer antigen 125 (CA-125) (1260 IU/mL) and carbohydrate antigen
19-9 (62.5 IU/mL). Although neither cytological nor microbiological abnormalities
were detected in the transudative ascitic fluid, a magnetic resonance imaging
scan and a more invasive diagnostic procedure using exploratory laparotomy
were performed. No abdominal or pelvic malignancy could be defined to explain
the extremely elevated CA-125 levels. The patient was finally diagnosed as
having mixed connective tissue disease (MCTD) based on the presence of antinuclear
ribonucleoprotein antibody, serositis leading to protein-losing enteropathy,
probable Raynaud phenomenon, and the absence of clinical and serological evidence
of other autoimmune diseases.
Cancer antigen 125 is a high-molecular-weight glycoprotein . . . [Full Text of this Article] Corresponding author: Alper Sevinc, MD, Department of Internal Medicine,
Inonu University, School of Medicine, Turgut Ozal Medical Center, Malatya,
TR-44069, Turkey (e-mail: asevinc@inonu.edu.tr). Corresponding author: Y. L. Kwong, MD, University Department of Medicine,
Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong (e-mail: ylkwong@hkucc.hku.hk).
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
HLA-G Is a Potential Tumor Marker in Malignant Ascites
Singer et al.
Clin. Cancer Res. 2003;9:4460-4464.
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