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Arch Intern Med. 2001;161:2619.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

During 15 years (1985-2000), 102 cases of drug-induced agranulocytosis have been registered in a prospective cohort study (partial data previously published¹). Twenty-one cases of antibiotic-induced agranulocytosis have been registered. All cases were notified in the Centre de Pharmacovigilance d'Alsace, Alsace, France. Clinical characteristics of these 21 cases of antibiotic-induced agranulocytosis are herein described.

Antibiotics incriminated were sulfamethoxazole (n = 9), amoxicillin (with and without clavulanate) (n = 3), imipenem (n = 2), cefotaxime sodium (n = 2), ceftriaxone sodium (n = 1), ceftazidime (n = 1), piperacillin (n = 1), vancomycin (n = 1), and tinidazole (n = 1). The mean (SD) duration of the antibiotic intake was 12 (6) days (range, 3-29 days).

The median age of the patients was 68 years (range, 22-93 years) and the male-female ratio was 0.75. Main clinical characteristics included isolated high fever (n = 9), septicemia or septic shock (n = 6), . . . [Full Text of this Article]

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