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	Since this article does not have an abstract, we have provided the first 115 words of the full text and any section headings.

Madaio and Harrington list captopril as a major cause of nephrotic syndrome in their review of the diagnosis of glomerular diseases.¹ Publications supporting captopril-induced nephrotic syndrome appeared in the 1980s after the introduction of the drug. Subsequent data have failed to support this concept.²

While it is not possible to prove the negative, captopril-induced proteinuria should be considered to be extremely rare, if it occurs at all.

The advantages of angiotensin-converting enzyme inhibition, including that achieved with captopril, have now been extensively documented. The benefits associated with its use should not be ignored because of concern about this adverse effect that has been poorly documented, if at all.

Barry J. Materson, MD, MBA
Miami, Fla

1. Madaio MP, Harrington JT. The diagnosis of glomerular diseases: acute glomerulonephritis and the nephrotic syndrome. Arch Intern Med. 2001;161:25-34. FREE FULL TEXT 2. Preston RA, Materson BJ, Reda DJ, Hamburger RJ, Williams DW, Smith MH. Proteinuria in mild to moderate hypertension: results of the VA cooperative study of six antihypertensive agents and placebo. Clin Nephrol. 1997;47:310-315. ISI | PUBMED

Arch Intern Med. 2001;161:2635.

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The Diagnosis of Glomerular Diseases: Acute Glomerulonephritis and the Nephrotic Syndrome
Michael P. Madaio and John T. Harrington
Arch Intern Med. 2001;161(1):25-34.
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