This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on ISI (5)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Drug Therapy, Other  • HIV/AIDS  • Treatment Adherence  • Adherence  • Alert me on articles by topic

Arch Intern Med. 2001;161:2738-2739.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Vertical transmission of human immunodeficiency virus type 1 (HIV-1) results from the interplay of virologic, immunologic, and pharmacological factors. Thus, HIV-1 variants are under selection for their ability to grow to high levels within the mother and for their ability to initiate a new infection within the infant. The use of antiretroviral drugs during pregnancy adds another level of selection to this process, wherein the ability to efficiently grow in the presence of the drug may select for mutants with altered fitness for spreading to infants.

Report of Cases

We have studied the vertical transmission of drug-resistant variants from 2 mothers to their infants. Population-based sequencing of viral reverse transcriptase and protease genes derived from plasma viral RNA was carried out (HIV Genotyping System, Version 2; PE Biosystem, Foster City, Calif). We obtained reverse transcriptase gene sequences for mothers and their infants. All sequences showed a full-length open reading frame.

The first mother . . . [Full Text of this Article]

Comment

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Sleep Disturbance and Depression as Barriers to Adherence
Phillips et al.
Clin Nurs Res 2005;14:273-293.
ABSTRACT  

Mother to Child Transmission of HIV
Newberry and Kelsey
Journal of Pharmacy Practice 2003;16:182-190.
ABSTRACT