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  Vol. 161 No. 4, February 26, 2001 TABLE OF CONTENTS
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Fluoxetine (Prozac) as a Cause of QT Prolongation

Arch Intern Med. 2001;161:612.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A variety of drugs have been identified as the cause of QT prolongation and of risk of life-threatening ventricular arrhythmias. This association is recognized for selected psychotherapeutic agents such as phenothiazines and tricyclics. Antidepressant drugs that inhibit the central nervous system neuronal uptake of serotonin have not been reported to have this effect on the QT interval.1

Report of a Case

A 52-year-old man had preoperative risk assesment for elective prostate surgery. Findings from physicial examination were normal, but those from an electrocardiogram (ECG) showed broad-based T waves and a markedly prolonged QTc interval of 0.56 second. An ECG recorded 3 months previously when treatment with fluoxetine hydrochloride (Prozac) was started (20 mg for 2 weeks and then 40 mg/d) for the management of depression showed a normal QTc interval of 0.38 second. In addition, single-drug therapy with verapamil hydrochloride, 240 mg, had been started 3 years earlier for essential hypertension (stage 1) and . . . [Full Text of this Article]


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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Antenatal Use of Selective Serotonin-Reuptake Inhibitors and QT Interval Prolongation in Newborns
Dubnov-Raz et al.
Pediatrics 2008;122:e710-e715.
ABSTRACT | FULL TEXT  

Association of antipsychotic and antidepressant drugs with Q-T interval prolongation
Zemrak and Kenna
Am J Health Syst Pharm 2008;65:1029-1038.
ABSTRACT | FULL TEXT  

QTc Prolongation and Torsades de Pointes in an Elderly Woman Taking Fluoxetine
WILTING et al.
Am. J. Psychiatry 2006;163:325-325.
FULL TEXT  

Prolonged QT interval in an infant of a fluoxetine treated mother
Dubnov et al.
Arch. Dis. Child. 2005;90:972-973.
ABSTRACT | FULL TEXT  

The Antidepressant Drug Fluoxetine Is an Inhibitor of Human Ether-A-Go-Go-Related Gene (HERG) Potassium Channels
Thomas et al.
J. Pharmacol. Exp. Ther. 2002;300:543-548.
ABSTRACT | FULL TEXT  





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