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Arch Intern Med. 2001;161:767-768.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

DIDMOAD syndrome is defined by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.¹ It is inherited as an autosomal recessive trait with varying expressivity. We report an interesting case involving a patient with type 1 diabetes with DIDMOAD syndrome–like manifestations.

Report of a Case

A 74-year-old woman (height, 146 cm; body weight, 37.4 kg) presented with DIDMOAD syndrome–like manifestations. Two of her 3 children had diabetes mellitus, but her parents and siblings did not. She developed diabetes mellitus, diabetes insipidus, and deafness when she was 50, 72, and 60 years old, respectively. She had been treated with diet and oral hypoglycemic agents for 10 years before she required insulin. At presentation, her fasting serum C-peptide level was 0.8 nmol/1 (2.4 ng/mL) (reference range, 0.3-0.8 nmol/L [0.9-2.4 ng/mL]). The results of laboratory investigations, including liver and renal function tests and measurement of serum lactate and pyruvate levels, were within normal ranges. Antibodies to glutamic acid . . . [Full Text of this Article]

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