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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with interest the review by Gaster and Holroyd¹ on St John's wort for mental depression and the correspondence on the matter by Cheng² and by Vormfelde and Poser.³ We agree with Vormfelde and Poser that the reference list of the article by Gaster and Holroyd is not up to date; however, Vormfelde and Poser also do not seem to be aware that the effect of Hypericum perforatum extract and hyperforin on serotonin (and dopamine) uptake has recently been questioned, thus raising doubts about the role that neurotransmitter uptake inhibition may have in the antidepressant effect of St John's wort.⁴

The response by Gaster⁵ is even less precise, as no quotations support the statement that "like hyperforin, several . . . substances have been shown to bind neuroreceptors in the brain and to inhibit the uptake of various neurotransmitters thought to be involved in depression." Even for the known . . . [Full Text of this Article]