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Bleeding Associated With Doxycycline and Warfarin Treatment
Arch Intern Med. 2001;161:1231.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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Select anti-infective agents such as co-trimoxazole, metronidazole,
select quinolones, macrolides, azole antifungal agents, and isoniazid have
been associated with prolonged international normalized ratio and/or bleeding.1 Few cases have been reported between doxycycline
and warfarin.2-3 We report
a case of possible retroperitoneal bleeding associated when these 2 drugs
were administered concurrently.
Report of a Case
A 69-year-old white woman presented to the hospital with a 3-day history
of left lower quadrant abdominal pain that was progressive, constant, and
exacerbated by movement. Six days prior to admission, the patient's physician
prescribed 100 mg of oral doxycycline twice daily for 10 days for bronchitis.
The patient's medical history included breast cancer, atrial fibrillation,
chronic obstructive pulmonary disease, myocardial infarction, rheumatoid arthritis,
osteoporosis, and diverticulosis. Long-term medications included warfarin,
diltiazem, atorvastatin, alendronate, albuterol, and fluticasone. One month
prior to admission, the international normalized ratio was 2.6.
Vital signs were normal except for a heart rate of 104 beats/min. . . . [Full Text of this Article]
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Probable Drug Interaction Between Warfarin and Hormonal Contraceptives
Zingone et al.
The Annals of Pharmacotherapy 2009;43:2096-2102.
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