
The Intravenous Use of Oral Acetylcysteine (Mucomyst) for the Treatment of Acetaminophen Overdose
Arch Intern Med. 2002;162:96-97.
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Acetaminophen remains one of the most common potentially lethal ingested
substances encountered in clinical practice.1
Treatment for acetaminophen poisoning in the United States has remained the
same during the past few years, while treatment outside the United States
has taken a different path. The clinical standard between the United States
and other countries differs in regard to intravenous acetylcysteine. The oral
acetylcysteine protocol used in the United States has been effective. However,
there are certain conditions, such as severe vomiting, for which oral administration
is not possible. Great Britain and Canada use an intravenous formulation of
acetylcysteine that has been available for many years.2
Intravenous acetylcysteine is not approved by the Food and Drug Administration
(FDA), but certain instances have arisen during which the use of oral acetylcysteine
intravenously has been potentially lifesaving.
Report of a Case
An 18-year-old woman presented to the emergency department 4 hours after
ingesting 50 extra-strength acetaminophen tablets (25 . . . [Full Text of this Article] Comment
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