 |
|
Allopurinol Hypersensitivity Syndrome Associated With Pancreatic Exocrine Abnormalities and New-Onset Diabetes Mellitus
Lisa M. Sommers, BS;
Robert B. Schoene, MD
Arch Intern Med. 2002;162:1190-1192.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
INTRODUCTION
Allopurinol, a xanthine oxidase inhibitor, has been in use since 1963
as an effective treatment to lower uric acid levels in patients with gout.1 Severe and occasionally fatal adverse reactions have
been attributed to allopurinol use in 1 of 260 patients and include agranulocytosis,
granulomatous hepatitis, and a systemic hypersensitivity syndrome known as
the allopurinol hypersensitivity syndrome (AHS),2
which most frequently develops within days to weeks after initiating allopurinol
therapy.3 The syndrome initially manifests
with a rash, ranging from an intensely pruritic maculopapular rash to toxic
epidermal necrolysis.3 Associated with rash
are fever, leukocytosis, eosinophilia, evidence of acute hepatic injury, and
renal dysfunction.1, 3-4
We describe for the first time a patient with AHS who, along with having the
common features of AHS, developed concurrent elevations in pancreatic exocrine
enzyme level and new-onset type 1 diabetes mellitus.
REPORT OF A CASE
While receiving treatment for hypertension, a . . . [Full Text of this Article]
COMMENT
From the Department of Medicine, University of Washington School of
Medicine, Seattle.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Minocycline-Induced Drug Hypersensitivity Syndrome Followed by Multiple Autoimmune Sequelae
Brown et al.
Arch Dermatol 2009;145:63-66.
ABSTRACT
| FULL TEXT
Allopurinol and diabetes -- a personal perspective
Gibson
British Journal of Diabetes & Vascular Disease 2004;4:422-422.
|
