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  Vol. 162 No. 10, May 27, 2002 TABLE OF CONTENTS
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Allopurinol Hypersensitivity Syndrome Associated With Pancreatic Exocrine Abnormalities and New-Onset Diabetes Mellitus

Lisa M. Sommers, BS; Robert B. Schoene, MD

Arch Intern Med. 2002;162:1190-1192.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Allopurinol, a xanthine oxidase inhibitor, has been in use since 1963 as an effective treatment to lower uric acid levels in patients with gout.1 Severe and occasionally fatal adverse reactions have been attributed to allopurinol use in 1 of 260 patients and include agranulocytosis, granulomatous hepatitis, and a systemic hypersensitivity syndrome known as the allopurinol hypersensitivity syndrome (AHS),2 which most frequently develops within days to weeks after initiating allopurinol therapy.3 The syndrome initially manifests with a rash, ranging from an intensely pruritic maculopapular rash to toxic epidermal necrolysis.3 Associated with rash are fever, leukocytosis, eosinophilia, evidence of acute hepatic injury, and renal dysfunction.1, 3-4 We describe for the first time a patient with AHS who, along with having the common features of AHS, developed concurrent elevations in pancreatic exocrine enzyme level and new-onset type 1 diabetes mellitus.


REPORT OF A CASE

While receiving treatment for hypertension, a . . . [Full Text of this Article]

COMMENT

From the Department of Medicine, University of Washington School of Medicine, Seattle.



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Minocycline-Induced Drug Hypersensitivity Syndrome Followed by Multiple Autoimmune Sequelae
Brown et al.
Arch Dermatol 2009;145:63-66.
ABSTRACT | FULL TEXT  

Allopurinol and diabetes -- a personal perspective
Gibson
British Journal of Diabetes & Vascular Disease 2004;4:422-422.
 





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