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The Effect of Alcohol on Acetaminophen Hepatotoxicity
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In the recent article by Kuffner et al,1
the authors examined the effect of alcohol abuse on the hepatotoxicity of
a standard dose of acetaminophen. In their study they administered the recommended
dose of 1 g/d to individuals who reported chronic excessive alcohol intake.
They reported that based on the failure of the aspartate aminotransferase
and alanine aminotransferase levels to increase, there was no evidence of
liver injury. They also stated that their results would suggest that, contrary
to a large number of reports from other workers, high alcohol consumption
does not enhance acetaminophen toxicity. I do not believe that they have sufficient
data to warrant this conclusion.
First, as we noted in our original report in JAMA,2
one of the factors that led us to initially propose that heavy alcohol consumption
was associated with enhanced acetaminophen toxicity was the observation that
there was a group of patients, all . . . [Full Text of this Article]
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