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Alcohol, Acetaminophen, and Toxic Effects on the Liver
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Although we do not dispute the factual results of the recently published
study by Kuffner et al,1 "Effect of Maximum
Daily Doses of Acetaminophen on the Liver of Alcoholic Patients," the conclusions
reached by the authors, as well as their recommendations concerning alcohol
consumption and acetaminophen, are of great concern and might pose a potential
public health hazard. It is well known that acetaminophen possesses a narrow
therapeutic index, and the potential for hepatoxicity can vary greatly among
individuals, depending upon the clinical environmental situation. For example,
persons with chronic alcoholism or persons with low caloric intake could become
glutathione deficient and as a result be potentially more susceptible to acetaminophen-related
hepatotoxicity. While doubling the 4-g maximum daily therapeutic dose is known
to cause liver injury, in some individuals predisposed to hepatotoxicity,
the tolerable dose may actually be significantly lower.2-3
The investigators have examined the effect of the maximum daily . . . [Full Text of this Article]
RELATED ARTICLE
Effect of Maximal Daily Doses of Acetaminophen on the Liver of Alcoholic Patients: A Randomized, Double-blind, Placebo-Controlled Trial
Edwin K. Kuffner, Richard C. Dart, Gregory M. Bogdan, Robert E. Hill, Edmund Casper, and Lisa Darton
Arch Intern Med. 2001;161(18):2247-2252.
ABSTRACT
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