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Statin Therapy in Older Persons
Pertinent Issues
Arch Intern Med. 2002;162:1329-1331.
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HYDROXYMETHYLGLUTARYL COENZYME A reductase inhibitors (statins) are
a marvel of modern medicine. They effectively lower serum low-density lipoprotein
(LDL) concentrations with a high level of safety. Several large clinical trials
document conclusively that statins reduce risk for major coronary events (myocardial
infarction and unstable angina) by at least one third.1-5
This risk reduction occurs even for patients with established coronary heart
disease (CHD).1-3
In fact, statins have been shown to lower risk for CHD in all subgroups—people
with and without established CHD, men and women, persons with and without
risk factors including diabetes mellitus, and people with lower as well as
higher cholesterol levels. This apparent universal efficacy has led to widespread
use of statins in clinical practice.
An extremely important question for preventive cardiology is whether
statins will reduce the risk for major coronary syndromes in older persons
( 65 years). Most coronary morbidity and mortality occurs after age . . . [Full Text of this Article]
RELATED ARTICLE
Therapy With Hydroxymethylglutaryl Coenzyme A Reductase Inhibitors (Statins) and Associated Risk of Incident Cardiovascular Events in Older Adults: Evidence From the Cardiovascular Health Study
Rozenn N. Lemaitre, Bruce M. Psaty, Susan R. Heckbert, Richard A. Kronmal, Anne B. Newman, and Gregory L. Burke
Arch Intern Med. 2002;162(12):1395-1400.
ABSTRACT
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ABSTRACT
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Benefits of Lipid Lowering in Older Patients Without CAD
Journal Watch Cardiology 2002;2002:3-3.
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