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  Vol. 162 No. 14, July 22, 2002 TABLE OF CONTENTS
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Monoamine Oxidase Deficiency: A Cause of Symptomatic Hyperserotoninemia in the Absence of Carcinoid

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Cheung and Earl1 describe a family consisting of a mother and 2 sons exhibiting similar clinical and biochemical manifestations, which these authors suggest constitute a syndrome due to an inherited monoamine oxidase (MAO) deficiency. Elevated blood serotonin and normal or low-normal urinary 5-hydroxyindoleacetic acid (5-HIAA) levels are noted in all 3 subjects who manifest symptoms reminiscent of carcinoid syndrome, presumably largely due to their excess of circulating serotonin. These clinical features are long-term recurrent episodic facial flushing, headache, diarrhea, and psychiatric symptoms. The sons in particular are described as exhibiting symptoms strongly suggestive of attention-deficit/hyperactivity disorder.

Biochemical and imaging studies for carcinoid tumor, pheochromocytoma, and other humoral causes of the symptoms are negative. A slight increase in 24-hour urinary normetanephrine level is seen in the 2 sons. However, that is not inconsistent with reduced MAO activity.

The authors treated the mother and 1 son with sertraline hydrochloride on the rationale . . . [Full Text of this Article]



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RELATED ARTICLE

Monoamine Oxidase Deficiency: A Cause of Flushing and Attention-Deficit/ Hyperactivity Disorder?
N. Wah Cheung and John Earl
Arch Intern Med. 2001;161(20):2503-2504.
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