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Association Between Folic Acid Food Fortification and Hypertension or Preeclampsia in Pregnancy
Arch Intern Med. 2002;162:1776-1777.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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From April 1990 to March 2000, the overall rate of preeclampsia did
not significantly change before (3.8%) and after (3.7%) the introduction of
a mandatory Canadian folic acid food fortification program in January 1998.
Background
Both folate deficiency and elevated plasma homocysteine are associated
with an increased risk of the placenta-mediated diseases of pregnancy, including
preeclampsia-eclampsia (PET).1 By January
1998, flour producers were fortifying all Canadian flour in compliance with
a mandatory national program, providing an additional daily average of 0.1
mg of folic acid (G. Carson, Robin Hood Multifoods Inc, Markham, Ontario,
written communication, August 2000). We conducted a retrospective population-based
longitudinal study to assess whether the introduction of this folic acid fortification
program was associated with a decline in the rate of PET and all hypertensive
disorders of pregnancy.
Materials and Methods
We evaluated the monthly hospitalization rates of PET and all types
of hypertension in pregnancy for the province of Ontario, . . . [Full Text of this Article]
Results
Comment
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease
Refsum et al.
J. Nutr. 2006;136:1731S-1740S.
ABSTRACT
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Folate and human reproduction
Tamura and Picciano
Am. J. Clin. Nutr. 2006;83:993-1016.
ABSTRACT
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