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The Potential Role of Fondaparinux as Venous Thromboembolism Prophylaxis After Total Hip or Knee Replacement or Hip Fracture Surgery
Arch Intern Med. 2002;162:1806-1808.
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VENOUS THROMBOEMBOLISM (VTE) is a common disease, with an average annual
incidence of over 1 per 1000.1 Venous thromboembolism
also is a potentially lethal disease, mostly owing to pulmonary embolism (PE).
Almost one quarter of all PE cases present as essentially sudden death, with
a 1-week survival of only 71%.2 Patients with
deep vein thrombosis (DVT) often experience serious and costly long-term complications.
Almost 30% of patients develop serious venous stasis syndrome within 10 years3-4 at an estimated cost of over $4000
per episode in 1997 dollars.5 To improve survival
and prevent complications, the incidence of VTE must be reduced.
Of the total burden of VTE occurring in the community, 50% arises in
either hospitalized or recently hospitalized patients.6
The incidence of VTE is over 100-fold higher among hospitalized patients compared
with community residents.7 Of all independent
risk factors for VTE, surgery conveys the highest risk,8
and major orthopedic leg . . . [Full Text of this Article] PHARMACOLOGIC PROPERTIES OF FONDAPARINUX AND CLINICAL STUDIES
CONCLUSIONS
RELATED LETTER
Fondaparinux Requires Further Study Before Firm Recommendation
Steven J. Hughes
Arch Intern Med. 2003;163(4):498.
EXTRACT
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RELATED ARTICLE
Fondaparinux vs Enoxaparin for the Prevention of Venous Thromboembolism in Major Orthopedic Surgery: A Meta-analysis of 4 Randomized Double-blind Studies
Alexander G. G. Turpie, Kenneth A. Bauer, Bengt I. Eriksson, Michael R. Lassen, and for the Steering Committees of the Pentasaccharide Orthopedic Prophylaxis Studies
Arch Intern Med. 2002;162(16):1833-1840.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Fondaparinux Requires Further Study Before Firm Recommendation
Hughes
Arch Intern Med 2003;163:498-498.
FULL TEXT
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