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We read with interest the recent commentary by Kushner and Sehgal¹ regarding the use of high-sensitivity C-reactive protein (hs-CRP) as a screening test for cardiovascular risk. Interestingly, many of the arguments lodged against the use of hs-CRP are the same as the ones initially used against measurement of cholesterol levels. Numerous studies in diverse populations have shown the value of hs-CRP in predicting risk, independent of other established markers.² Even an incremental ability to prognosticate risk above and beyond stress testing and coronary angiography has been demonstrated.^3-5 High-sensitivity CRP has now been proven to predict the risk of sudden cardiac death, a major cause of mortality that lacks effective preventive therapies.⁶ Furthermore, it appears that CRP is not just an innocent bystander in atherosclerosis, but actually has a direct pathogenic role in arterial disease.⁷ Studies have documented the ability of CRP to activate complement, to increase the uptake of low-density . . . [Full Text of this Article]

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RELATED ARTICLE

Is High-Sensitivity C-Reactive Protein an Effective Screening Test for Cardiovascular Risk?
Irving Kushner and Ashwini R. Sehgal
Arch Intern Med. 2002;162(8):867-869.
ABSTRACT | FULL TEXT