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The Serum Folate Response to the US Mandatory Fortification of Grain Products With Folic Acid
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Rader and Yetley, in their recent letter,1 conclude
that there is an inconsistency between the effect of increasing folic acid
intake on serum folate levels based on the results of our randomized trial,2 and the effect based on the results of Lawrence
and her colleagues,3-4 which
compares serum folate levels before and after mandatory grain fortification
with folic acid in the United States. Radar and Yetley take the view that
the increase in serum folate from 1994 to 1999 (an increase of more than 7.4
ng/mL, from 12.6 ng/mL in 1994 and >20.0 ng/mL in 1999) reported by Lawrence
and her colleagues is attributable to US grain fortification of flour that
was introduced over 1996 and 1997 and was designed to increase the daily intake
of folic acid by 0.1 mg/d. From our trial, an increased serum folate level
of about 2.4 ng/mL would be expected for a 0.1-mg/d increase . . . [Full Text of this Article]
RELATED ARTICLE
Nationwide Folate Fortification Has Complex Ramifications and Requires Careful Monitoring Over Time
Jeanne I. Rader and Elizabeth A. Yetley
Arch Intern Med. 2002;162(5):608-609.
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