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Arch Intern Med. 2002;162:358-359.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Metoclopramide hydrochloride, a dopamine D2–like receptor antagonist, is a well-known prokinetic drug. Extrapyramidal side effects due to metoclopramide are not frequently reported.^1-2 Although not widely appreciated in the literature, patients with the acquired immunodeficiency syndrome (AIDS) appear to be more susceptible for extrapyramidal side effects. This is illustrated in 3 patients with AIDS, who presented with acute dystonia due to metoclopramide use, within a period of 8 months.

Report of Cases

Patient 1

A 34-year-old man presented with abdominal pain. Analysis revealed pancreatitis due to infection with Mycobacterium tuberculosis. A human immunodeficiency virus (HIV) test was positive with a CD4 cell count of 50/µL. Because of nausea, metoclopramide hydrochloride was prescribed in a dose of 10 mg orally 3 times a day. After 2 days he developed severe anxiety, trismus, and spastic dysarthria. Biperiden was given and metoclopramide treatment was stopped. All symptoms disappeared.

Patient 2

A 47-year-old homosexual man was admitted with fever and cough. . . . [Full Text of this Article]

Patient 3

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