What Is C-Reactive Protein Telling Us About Coronary Artery Disease?
Arch Intern Med. 2002;162:389-392.
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HUMAN C-reactive protein (CRP) was originally observed in the plasma
of patients with acute infections and was found to react with the C-polysaccharide
of the pneumococcus.1 It is an acute-phase
reactant, because of the pronounced rise in concentration after tissue injury
or inflammation. This diagnostically sensitive but nonspecific marker for
inflammation is produced primarily by the liver but also by lymphocytes.2 C-reactive protein appears to recognize both foreign
pathogens and damaged host cells and can initiate their elimination by interacting
with humoral and cellular effector systems in the blood.3
The work of Ross and others has clearly shown that arteriosclerosis involves
a chronic inflammatory process.4 Thus, it is
not surprising that a series of studies have now found a significant positive
relationship between CRP concentration and coronary artery disease (CAD),5-6 although it remains unclear that this
relationship is independent of other inflammatory markers.7
Hence, a 70-year-old test used to detect . . . [Full Text of this Article]DISEASE DISCRIMINATION AND REFERENCE INTERVALS
SPECIFICITY AND POSITIVE PREDICTIVE VALUE
UNSTABLE CORONARY SYNDROMES
CRP FUNCTION IN CAD
CONCLUSIONS
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Arch Intern Med. 2003;163(2):242.
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