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Increased Blood Pressure Variability May Be Associated With Cognitive Decline in Hypertensive Elderly Subjects With No Dementia
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As Birkenhäger and colleagues1
suggested in their article, the decrement of blood pressure (BP) occurring
in patients with hypertension in the phases shortly before dementia may be
related to a central dysregulation of prefrontal autonomic centers. To contribute
to this topic, we have studied the relationship between cognitive function
and BP variability, which is known to reflect an altered baroreflex sensitivity.2 We evaluated 34 elderly patients consecutively
admitted to our hospital with no dementia (normal or mild cognitive impairment
according to the Petersen criteria).3 All
patients underwent a neuropsychological assessment to evaluate cognitive functions
(Table 1) and a noninvasive, 24-hour
BP monitoring (using the Intermed Takeda TM-2430; A & D Instruments Ltd,
Abingdon, Oxford, England) to determine the circadian BP profile.
Table appears in full text version.
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Clinical Characteristics of 34 Patients With Absent or Mild Cognitive
Impairment Stratified by Mini-Mental State Examination (MMSE) Scores Adjusted
for Age and Sex*
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The daytime BP measurements . . . [Full Text of this Article]
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