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In their recent study of the effects of folic acid on reduction in homocysteine concentrations, Wald et al¹ randomized 151 patients with ischemic heart disease to dosages of folic acid of 0.2 to 0.8 mg/d or placebo and measured serum homocysteine levels at baseline, after 3 months of supplementation, and 3 months after folic acid use was discontinued. Median serum homocysteine levels decreased with increasing folic acid dosage to a maximum of 0.8 mg/d of folic acid, at which point a 23% reduction in homocysteine level was observed. Wald et al¹ concluded that a dosage of 0.8 mg/d of folic acid was necessary to achieve the maximum reduction in serum homocysteine level. Wald et al further stated that current US food fortification levels (0.14 mg of folic acid/100 g of cereal-grain product) will achieve only a small proportion of the achievable homocysteine-lowering effect and that the higher level of fortification . . . [Full Text of this Article]

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The Serum Folate Response to the US Mandatory Fortification of Grain Products With Folic Acid
David Wald, Malcolm Law, and Nicholas Wald
Arch Intern Med. 2002;162(19):2254.
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The Serum Folate Response to the US Mandatory Fortification of Grain Products With Folic Acid
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