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Miura and colleagues¹ add persuasively to the small number of studies that illustrate that even moderately elevated blood pressure (BP) in early life increases cardiovascular disease risk. The authors state that the only prospective studies of the association between BP in young adulthood and cardiovascular disease mortality are nested case-control investigations and analyses of life insurance data. However, in the "Comment" section they cite our study of this issue among male former students attending Glasgow University, Scotland, from 1948 to 1968. This is a large prospective cohort study in which BP was measured at a mean age of 20.5 years—on average more than 9 years earlier than in the Chicago study. As noted by the authors, we found a positive association between systolic BP and coronary heart disease mortality.² In addition, our findings provide evidence that both systolic and diastolic BP are positively associated with cardiovascular disease and coronary heart . . . [Full Text of this Article]

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